High-Dose Inactivated Influenza Vaccine Reduces Hospitalization Rates in Heart Failure Patients
A study published in Circulation: Heart Failure found that high-dose inactivated influenza vaccine (HD-IIV) is associated with lower rates of hospitalization related to laboratory-confirmed influenza, cardiorespiratory disease, cardiovascular disease, and heart failure in patients with heart failure.
The study analyzed data from the DANFLU-2 trial, which included individuals aged 65 years and older who received either HD-IIV or standard-dose inactivated influenza vaccine (SD-IIV) during three consecutive influenza seasons (2022-2025) in Denmark.
The findings suggest that HD-IIV is linked to decreased risk for hospitalization in patients with heart failure.
- The study was a prespecified exploratory analysis of the DANFLU-2 trial.
- The trial included individuals aged 65 years and older.
- Participants were randomly assigned to receive HD-IIV or SD-IIV.
Author's summary: High-dose flu vaccine reduces hospitalization rates in heart failure patients.
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