Early initiation of TNF inhibitors among children with non-sJIA led to significant and sustained improvements in disease activity.
Researchers found that early initiation of tumor necrosis factor (TNF) inhibitor therapy among children diagnosed with nonsystemic juvenile idiopathic arthritis (non-sJIA) at 2 years or less leads to significant and sustained improvements in disease activity.
The study, presented at the American College of Rheumatology (ACR) Convergence 2025, analyzed data from the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry from 2015 to 2023.
Outcomes comparable to patients who received treatment later in life and those not exposed to TNF inhibitors.
Author's summary: Early TNF inhibitor use improves outcomes in nonsystemic JIA patients.