Amphista Therapeutics’ successful degradation of a key cancer target, BRD9, via a novel mechanism with DCAF16 E3 ligase published in Nature Communications

Amphista Therapeutics Achieves Breakthrough in Cancer Target Degradation

Amphista Therapeutics, a leader in next-generation targeted protein degradation (TPD), has published a study in Nature Communications demonstrating a novel mechanism for degrading the key cancer target BRD9 using its proprietary Targeted Glue small molecule degrader.

The company's Chief Scientific Officer, Louise Modis, PhD, commented:

The deep expertise of our scientists led to the successful integration of the favorable performance characteristics of earlier generation PROTACs and conventional molecular glues but with key limitations designed-out.

Author's summary: Amphista Therapeutics publishes breakthrough cancer research.

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Kauppalehti Kauppalehti — 2025-10-27

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