NFL Picks and Predictions for Week 6
The NFL season continues with a highly-anticipated slate of games in Week 6. Here are 3 plus-money bets to consider before kickoff.
By Spenser Davis, published on Oct 12, 2025.
Week 6 NFL Bold Predictions
Last week, our NFL bold predictions went 2-1 and came out +1.17 units overall. Since the start of Week 3, picks in this story are up 2.16 units.
This Week's Picks
Here are 3 bold predictions for this week in the NFL:
- Fading the Colts offense, despite their current average of 3.39 points per drive, which would be the most this century if maintained all season long.
Indianapolis is currently averaging 3.39 points per drive. That would be by far the most this century if the Colts are able to keep up this pace all season long.
Author's summary: Week 6 NFL picks and predictions.
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