Overview
From 1 January to 26 October 2025, a total of 565,404 confirmed cholera cases and 7,074 deaths were recorded across 32 countries in five WHO regions. This data highlights the ongoing global spread of cholera and the continued need for coordinated public health responses.
Geographic Distribution
Cholera outbreaks were reported across multiple continents. The African Region remained the most affected, accounting for the vast majority of cases and deaths. Countries in the Eastern Mediterranean, South-East Asia, and Americas regions also registered new cases, showing sustained transmission patterns.
Current Situation and Trends
Although some countries observed a decline in weekly case numbers, several areas continue to experience active or resurfacing transmission. Persistent social and environmental factors—such as limited access to clean water, poor sanitation, and population displacement—contribute to ongoing outbreaks.
Response Efforts
WHO, in collaboration with health ministries and partners, continues to:
- Support rapid response teams for outbreak investigation and containment.
- Enhance logistical support for Oral Cholera Vaccine (OCV) distribution.
- Strengthen surveillance and laboratory capacities.
- Facilitate community-level awareness campaigns to promote hygiene and sanitation.
Global Health Challenges
The global vaccine supply remains under pressure, leading to targeted single-dose vaccination strategies in high-risk areas. Ongoing conflicts, climate-related disasters, and crowded living conditions increase vulnerability to future surges.
Key Quote
“The persistence of cholera in multiple regions underscores the urgent need for sustainable water and sanitation infrastructure,” stated WHO in its 32nd situation report.
Author summary: Between January and October 2025, over half a million cholera cases were reported in 32 nations, emphasizing the global need for clean water, vaccination access, and stronger health systems.
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