UTSA vs. South Florida odds, line: 2025 college football picks for Week 11 predictions from proven model - SportsLine.com

UTSA vs. South Florida Odds and Predictions for Week 11

The South Florida Bulls aim to remain contenders in the American Athletic Conference (AAC) championship race as they face the UTSA Roadrunners in a crucial Thursday night game.

Team Performances and Records

Betting Trends

Kickoff is scheduled for 7:30 p.m. at Raymond James Stadium in Tampa, Florida.

Historical Matchup

UTSA won the only prior match against South Florida with a decisive 49-21 victory in 2023.

Odds and Predictions

The SportsLine Projection Model simulates every FBS game 10,000 times and provides expert college football picks and betting advice.

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Author’s Summary

This key AAC matchup features South Florida as strong favorites looking to extend their home winning streak, while UTSA aims to avenge last year's defeat and improve their conference standing.

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SportsLine SportsLine — 2025-11-06