I can’t reliably fetch the very latest (last-days/weeks) news right now. However, here are a few recent, reputable research updates and review articles (mostly 2021–2022, plus one 2015 review) that specifically discuss hepcidin as an antimicrobial peptide (or hepcidin-derived antimicrobial peptides), including current themes and findings.
A 2021 review in Frontiers in Immunology summarizes work using hepcidins to prevent or treat bacterial infections, including infection models where one specific hepcidin variant (“hamp2” in that review) reduced mortality after bacterial challenge, while another variant (“hamp1”) was less protective or worse in their models.[2][3]
Work referenced in that same 2021 review notes that different hepcidin forms (hamp1 vs hamp2 variants) can show different antimicrobial profiles against Gram-positive vs Gram-negative bacteria, and investigators often select the most promising variant for further testing in vivo.[3]
A 2022 paper on identification of antibacterial activity of hepcidin discusses hepcidin’s structure (signal peptide, propeptide, mature peptide) and frames mature hepcidin as an antibacterial peptide and iron regulator.[5]
A 2015 review in Molecules focuses on the antimicrobial properties of hepcidins and highlights challenges for therapeutic use (e.g., synthesis complexity due to disulfide bonds, partial inhibition by body fluids, and needing relatively high active concentrations).[1]
To get truly up-to-date headlines (preprints, press releases, or new papers from the last few weeks), tell me which you mean by “news”:
And if you can, share whether you care about “hepcidin (HAMP)” only or also hepcidin-derived fragments/analog peptides.
The increasing frequency of multi-drug resistant microorganisms has driven research into alternative therapeutic strategies. In this respect, natural antimicrobial peptides (AMPs) hold much promise as candidates for the development of novel ...
pmc.ncbi.nlm.nih.govHepcidin is a small peptide composed of signal peptide, propeptide, and the bioactive mature peptide from N terminal to C terminal. Mature hepcidin is an ant...
www.frontiersin.orgBackground/Aims Hepcidin (gene name HAMP), an IL-6-inducible acute phase peptide with antimicrobial properties, is the key negative regulator of iron metabolism. Liver is the primary source of HAMP synthesis, but it is also produced by other tissues such as kidney or heart and is found in body fluids such as urine or cerebrospinal fluid. While the role of hepcidin in biliary system is unknown, a recent study demonstrated that conditional gp130-knockout mice display diminished hepcidin levels...
journals.plos.orgThe current treatments applied in aquaculture to limit disease dissemination are mostly based on the use of antibiotics, either as prophylactic or therapeuti...
www.frontiersin.orgThe current treatments applied in aquaculture to limit disease dissemination are mostly based on the use of antibiotics, either as prophylactic or therapeutic agents, with vaccines being available for a limited number of fish species and pathogens. Antimicrobial peptides are considered as promising …
pubmed.ncbi.nlm.nih.govHepcidin is a small peptide composed of signal peptide, propeptide, and the bioactive mature peptide from N terminal to C terminal. Mature hepcidin is an antibacterial peptide and iron regulator with eight highly conserved cysteines forming four ...
pmc.ncbi.nlm.nih.govThe current treatments applied in aquaculture to limit disease dissemination are mostly based on the use of antibiotics, either as prophylactic or therapeutic agents, with vaccines being available for a limited number of fish species and pathogens. ...
pmc.ncbi.nlm.nih.govAntimicrobial peptides (AMPs) are involved in the innate immunity of human body to battle microbial pathogens. In addition, human AMPs play also an im…
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